Yes…Colorado statutes say that you may have a loaded revolver or pistol in your vehicle no permit required. You are not however allowed to have a loaded long gun (rifle or shotgun) in your vehicle. Loaded in Colorado means chambered.
Get all the Colorado regulations and your questions answered in my short class Concealed Carry Rules, Regs & Tips. 2.5 hours
See the Colorado Do’s and Don’ts, A White Paper outlining important aspects of traveling with a gun in Colorado